This over-the-counter pain cream works on joint pain. It’s designed to soothe joint pain away, so you can get back to your active self, fast. Maximum strength Aspercreme is a topical pain relief cream. Trolamine salicylate 10% is the active ingredient, a topical analgesic. Trolamine is applied to where you need it, providing targeted therapy. Rub directly onto the affected area, such as your back or knee.